They're not viewed as lovely animals by most, but if you look at their faces rather than their tails, they do have a certain sweet charm. And they are North America's only marsupials, which is rather interesting and should garner them at least a little respect.
The Opossum Society of the United States advocates for greater understanding of these misunderstood beings, noting that increased development of formerly rural land infringes upon possum habitat and pushes them into greater contact with humans. Reasons to tolerate them include this nice little piece of advocacy from the OSUS:
Whether rural, residential or in the wilderness, opossums are a benefit to any area they inhabit. Their diet includes all types of bugs and insects including cockroaches, crickets and beetles. They love snails. They also eat mice and rats. The nocturnal opossum is attracted to our neighborhoods by the availability of water, pet food left out at night and overripe, rotting fruit that has fallen from trees. The opossum in turn helps keep our neighborhoods clean and free of unwanted, harmful garden pests and rodents, which may carry diseases. The opossum has earned the title of "Nature's Little Sanitation Engineer."Remember that, next time you see one flattened on the highway, and mourn just a little.